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Cobas® 8000 Modular Analyzer Series 1. Cobas 8000 Data Manager

Cobas® 8000 Modular Analyzer Series 1. Cobas 8000 Data Manager

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World’s Latest and Best Technologies by Roche



3. Cobas ISE Module

¾¾

¾¾

¾¾

¾¾



Sodium, potassium, and chloride

900 or 1,800 tests/hour

ISE-specific sample probe with clot detection

Independent processing line.



4. Cobas c 702 Module*

¾¾ More than 120 assays and applications on the clinical

chemistry platform including substrates, enzymes,

proteins, DATs, and TDMs

¾¾ Throughput of up to 2,000 tests/hour

¾¾ 70 reagent channels directly accessible for pipetting

¾¾ Specimen integrity via serum indices, clot and liquid

level detection

¾¾ Contact-free ultrasonic mixing.



4a. Reagent Manager

¾¾ 10 reagent positions

¾¾ Reagent RFID reader

¾¾ Continuous reagent cassette loading and unloading

during operation

¾¾ Reagent cassette decapping

¾¾ Reagent cassettes can be placed in the reagent manager

at any time and as convenient.



5. Cobas c 502 Module

¾¾ More than 120 assays and applications on the clinical

chemistry platform including substrates, enzymes,

proteins, DATs, TDMs, and electrolytes

¾¾ HbA1c (whole-blood measurement)

¾¾ Throughput of up to 600 tests/hour

¾¾ 60 reagent channels directly accessible for pipetting

¾¾ Automatic reagent loading and unloading during

operation



903



¾¾ Specimen integrity via serum indices, clot and liquid

level detection

¾¾ Contact-free ultrasonic mixing.



6. Cobas e 602 Module

¾¾ Heterogeneous immunochemistry testing with almost

100 assays for anemia, bone, tumor markers, hormones,

cardiac and infectious diseases

¾¾ 9 min. STAT applications for hsTnT, TnI, CK-MB, NTproBNP, Myoglobin, PTH and hCG

¾¾ Throughput of up to 170 tests/hour

¾¾ 25 reagent channels directly accessible for pipetting

¾¾ Carryover-free disposable tips

¾¾ Clot, liquid level, and air bubbles detection.



7. Module Sample Buffer

¾¾ Capacity for 20 sample racks resulting in additional

capacity of 100 samples per module

¾¾ Freely definable STAT positions

¾¾ Environmentally controlled compartment for 5 Auto

QC racks

¾¾ Backup operation port

¾¾ Switch gates for shortcuts; gripper for moving the racks

from line to line

¾¾ Random access to racks; racks can go from anywhere

to everywhere.



COBAS® 6000 ANALYZER SERIES

The Success Story Continues

Just as every patient requires individualized care, every

laboratory is unique. Striking a balance between high

standards and efficient operation requires tailor-made

solutions.



* Alternatively, cobas c 701 module can be used. It is based on the same technology and it offers the same number of channels as cobas c 702, but has

no reagent manager function.



904



Concise Book of Medical Laboratory Technology: Methods and Interpretations



PRODUCT CHARACTERISTICS

High System Reliability

¾¾ More than 9,000 systems installed worldwide

¾¾ Proactive automated maintenance for over 96 % uptime

including maintenance on a 24/7 basis.



Unique Reagent Concept

¾¾ No preparation and no mixing required, economic

usage with high stabilities and convenient kit sizes.



The cobas 6000 analyzer series is a member of the

cobas modular platform family. It offers medium to high

workload laboratories tailor-made solutions for clinical

chemistry and immunochemistry testing. Depending on

the configuration, the cobas 6000 analyzer series achieves

a throughput of up to 2.5 million tests per year. The cobas

6000 analyzer series is the result of vast knowhow and

decades of experience combined into one successful

concept. With over 9,000 systems worldwide, the success

story continues.



YOUR BENEFIT

Increased Efficiency

¾¾ Perfect fit of throughput and reagent channels achieved

across the 7 different configurations

¾¾ Consolidation of 98% of the serum work area testing on

Serum Work Area workloads

¾¾ Simplified lab processes and reduced costs.



Quality of Results

¾¾ That you can trust and are right the first time

¾¾ Predictable turnaround time

¾¾ Peace of mind.



Maximum Uptime

¾¾ Highly reliable system based on more than 35 years of

experience

¾¾ Superior support provided by Roche organizations

worldwide.



Optimized Workflow

¾¾ Wide range of pre- and post-analytical solutions and

complete IT solutions

¾¾ Workflow efficiency and reduced complexity.



First Class Performance

¾¾ State-of-the-art immunoassay testing using ECL

technology

¾¾ High quality results by ensuring sample and result

integrity.



Intelligent Sample Workflow

¾¾ Combines STAT with routine testing without disruption.



Professional Management of Lab Processes

¾¾ Wide range of complete pre- and post-analytical

solutions from small task target automation to total lab

automation.



1. Core unit

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Loading and unloading capacity of 150 samples

Throughput of up to 600 samples/hour

Dedicated STAT port

Simple operation with continuous loading and

unloading.



Delivers Customized Solutions for Various Work and

Testing Requirements



World’s Latest and Best Technologies by Roche



True Workflow Consolidation



905



4. Cobas e 601 Module

¾¾ More than 100 assays on the immunochemistry

platform including anemia, bone, tumor markers,

hormones, cardiac and infectious diseases

¾¾ 9 min. STAT applications for hsTnT, TnI, CK-MB, NTproBNP, Myoglobin, PTH and hCG

¾¾ Throughput of up to 170 tests/hour

¾¾ 25 reagent channels, directly accessible for pipetting

¾¾ Carryover-free disposable tips

¾¾ Clot, liquid level, and air bubble detection.



2. Rack rotor

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¾¾

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Capacity for 20 sample racks

Freely definable STAT positions

Option of 3 Auto QC racks

Random access for the racks.



3 Cobas c 501 Module

¾¾ ISE measurements (K, Na, Cl)

¾¾ More than 120 assays and applications on the clinical

chemistry platform including proteins, enzymes, DATs,

TDMs, substrates and electrolytes

¾¾ HbA1c (whole-blood measurement)

¾¾ Throughput of up to 1,000 tests/hour

¾¾ 60 reagent channels directly accessible for pipetting

¾¾ Automatic reagent loading and unloading during

operation

¾¾ Specimen integrity via serum indices, clot and liquid

level detection

¾¾ Contact-free ultrasonic mixing.



Cobas p 312 Pre-analytical System is the Ideal

Companion for the cobas® 6000 Analyzer Series,

for a Fully Harmonized and Complete Solution

Safe and efficient workflows with minimum complexity,

using a single square meter footprint. The cobas p 312 preanalytical system is Roche’s answer to fulfill automation

needs of many small to mid-sized laboratories. It includes

the necessary functionality to significantly improve

laboratory organization and increase workflow efficiency.

This on a single square meter.

The simplicity of this solution and the small space

requirements allow its easy implementation in almost any

laboratory.

The cobas p 312 pre-analytical system will take over the

following key tasks:

¾¾ Sample registration at a single entry point

¾¾ Sorting and distribution of samples

¾¾ Recursive workflow

¾¾ Archiving.



906



Concise Book of Medical Laboratory Technology: Methods and Interpretations



COBAS® 4000 ANALYZER SERIES

Freedom to Realize Your Lab’s Potential

The cobas 4000 analyzer series is a member of the cobas

modular platform family and designed for laboratories

processing 25,000 to 500,000 tests per year or 50 to 250

samples per day. It consists of the cobas c 311 analyzer

for clinical chemistry and the cobas e 411 analyzer

for immunochemistry testing. Together with cobas IT

solutions and the ability to integrate the cobas p 312 preanalytical system, the cobas 4000 analyzer series provides

a comprehensive serum work area solution that takes

workflow efficiency to the next level.



YOUR BENEFIT

Increased Efficiency

¾¾ Consolidation of 98% or more of serum work area

workloads.



Maximum Uptime

¾¾ Highly reliable system based on more than 35 years of

experience

¾¾ Superior support by Roche organisations worldwide.



Quality of Results

¾¾ Integrated safety features for results you can trust

¾¾ Predictable turnaround time.



Cobas® 4000 Analyzer Series Solution



PRODUCT CHARACTERISTICS

COBAS C 311 ANALYZER

First Class Performance

¾¾ More than 120 assays and applications available

including DATs, TDMs, specific proteins and whole

blood HbA1c

¾¾ Throughput: up to 300 tests/h; ISE: 150 samples/h

(corresponding to 450 tests/h).



Intelligent Sample Workflow

¾¾ 108 sample positions with continuous random access

and flexible STAT priority settings.



Unique Reagent Concept

¾¾ Convenient and error-free handling of cobas c packs

¾¾ Economic usage with high stabilities and convenient

kit sizes.



High System Reliability

¾¾ Programable automated maintenance functionalities.



PRODUCT CHARACTERISTICS

COBAS E 411 ANALYZER

First Class Performance

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¾¾

¾¾

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Almost 100 assays available

Throughput: up to 86 tests/h

Superior immunoassay testing using ECL technology

9 min. STAT applications including Troponin, CK-MB,

Myoglobin, ß-hCG and PTH



World’s Latest and Best Technologies by Roche

¾¾ Disposable tips and cups for carryover-free sample

pipetting.



Intelligent Sample Workflow

¾¾ 75 sample positions (rack system)

¾¾ 30 sample positions (disk system)

¾¾ Continuous random access and flexible STAT priority

settings.



907



YOUR BENEFIT

High Quality of Results

¾¾ Comprehensive testing capabilities

¾¾ Results you can trust the first time, every time.



Increased Efficiency



Unique Reagent Concept



¾¾ Essential routine testing on a small footprint

¾¾ Simplified system operation.



¾¾ Convenient and error-free handling of cobas e packs

¾¾ Economic usage with high stabilities and convenient

kit sizes.



Maximum Uptime



High System Reliability



¾¾ Highly reliable system delivering >99 % uptime

¾¾ Superior support provided by Roche organisations

worldwide.



¾¾ More than 10,000 analyzers installed worldwide

¾¾ High uptime of 99.8%.



Optimized Workflow



COBAS C 111 ANALYZER

Small Box, Big Performance

The cobas c 111 analyzer is the smallest member of the

cobas serum work area platform family and the ideal

solution for clinical chemistry testing in laboratories

running 10 to 50 samples per day. With a comprehensive

test menu and easy integration of STAT samples, it

can support testing of both routine clinical chemistry

panels and rapid turnaround critical care markers. In

addition, the cobas c 111 analyzer uses the same reagent

formulations as the larger cobas clinical chemistry

analyzers. This standardizes patient results, which is vital

for integrated laboratory networks serving outpatient

services, emergency departments and clinics, as well as

private laboratories serving primary care physicians.



¾¾ Reducing complexity for a range of laboratories, both

networked or standalone

¾¾ Consistent results across the cobas platform.



PRODUCT CHARACTERISTICS

World-class Performance

¾¾ More than 40 assays and applications available

including whole blood HbA1c, hsCRP, and D-dimer

¾¾ Externally rated world-class performance1



Good Fit for Labs <50 samples/day

¾¾ Throughput of up to 100 tests/hour

¾¾ Compact benchtop system for labs with limited floor

space

¾¾ Easy, intuitive software handling



908



Concise Book of Medical Laboratory Technology: Methods and Interpretations



High System Reliability



Optimized Workflow



¾¾ Robust system design

¾¾ Wizard-guided maintenance procedures.



¾¾ Consistent results across the cobas platform.



Network Compatibility

¾¾ Ability to connect to local IT surroundings

¾¾ Common reagent chemistry across the cobas platform.



COBAS INTEGRA® 400 PLUS

The Specialist in the Routine Laboratory

The COBAS INTEGRA 400 plus analyzer is the perfect

solution for laboratories running 50 to 400 samples per

day. Its broad test menu comprises over 120 assays and

applications that consolidate clinical chemistry with

specific proteins, therapeutic drug monitoring and drug

of abuse testing. This compact tabletop analyzer offers

maximum versatility to improve efficiency and reduce

costs. It uses the convenient cobas c pack reagent format,

which standardizes patient results across integrated

laboratory networks.



YOUR BENEFIT

High Quality of Results

• Results you can trust the first time, and every time.



Increased Efficiency

¾¾ Comprehensive testing capabilities on a compact

footprint

¾¾ Simplified processes and reduced costs.



PRODUCT CHARACTERISTICS

First Class Performance

¾¾ More than 120 assays and applications available

including clinical chemistry, specific proteins, TDMs,

DATs and whole blood HbA1c.



Good Fit for Labs Processing 50 to 400 Samples/day

¾¾ Throughput of up to 400 tests/hour

¾¾ Compact benchtop system for labs with limited floor

space.



High System Reliability

¾¾ Robust system design

¾¾ Clot detection and pipetting safeguards.



World’s Latest and Best Technologies by Roche



909



greater consolidation by integrating analytical systems

with Roche pre-analytical and post-analytical systems.

Roche flexible and harmonized solutions allow every

laboratory to increase its efficiency without adding

complexity.

Stand-alone and connected solutions meet differing

needs, from sample entry to archiving. High quality and

predictable turnaround times are always ensured, together

with proven system reliability.



Unique Reagent Concept

¾¾ Convenient and error-free handling of cobas c packs

¾¾ Economic usage with high stabilities and convenient

kit sizes.



PERSONALIZED LAB AUTOMATION

Scalable Functionality that’s Just Right for Your Lab

The personalized lab automation portfolio offers turnkey

solutions specifically designed for laboratories which seek



Personalized Lab Automation—Stand-alone Solutions



910



Concise Book of Medical Laboratory Technology: Methods and Interpretations



Personalized Lab Automation—Connected Solutions

MODULAR® PRE-ANALYTICS EVO



MODULAR PRE-ANALYTICS EVO offers integration by automation solutions, consolidation of

analytics and process organization.



Cobas connection modules



Cobas connection modules use flexible conveyor units to connect cobas p 512 and cobas p

612 pre-analytical systems to laboratory analyzers and post-analytics.



Cobas® 8100 automated workflow series



Cobas 8100 automated workflow series features an intelligent sample routing workflow and

prioritization system.



Personalized Lab Automation—Post-analytics Solution

cobas p 501/p 701 post-analytical units



cobas p 501/p 701 post-analytical units are refrigerated archiving systems enabling sample

retrieval and add-on test management



COBAS P 312 PRE-ANALYTICAL SYSTEM

Pre-analytics on Small Footprint

Cobas p 312 pre-analytical system is a small footprint

standalone system for decapping, sorting and archiving of

sample tubes for SWA, hematology, coagulation, urinalysis

and blood screening.



Product Characteristics

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Throughput: up to 450 tubes/hour

Registration of primary samples

Selective decapping

Flexible sorting with tube barcode alignment:

• Out of centrifuge buckets

• Into and out of analyzer’s target racks



¾¾ Remote access for error handling and service

¾¾ Archiving of samples (recursive workflow).



COBAS P 512 PRE-ANALYTICAL SYSTEM

Pre-analytics to Increase Efficiency

Cobas p 512 is a standalone or connectable, fully automated pre-analytical system which offers a highspeed

solution for high-throughput laboratories.



PRODUCT CHARACTERISTICS

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Throughput: up to 1,100 samples/hour

Registration of primary samples

Selective decapping of sample tubes

Orientation of barcode in a “good-to-read” position

Sorting of tubes directly into analyzer’s target racks

Sorting of tubes with unreadable barcode, without test

requests or with insufficient sample to default.



World’s Latest and Best Technologies by Roche



911



COBAS P 512 PRE-ANALYTICAL SYSTEM WITH SINGLE CENTRIFUGE COBAS P 471 AND BULK LOADER MODULE



¾¾ Archiving of processed samples with optional recapping

¾¾ Optional: recapper, connection to single or double

centrifuge, connection to bulk loader module (BLM),

tube type identification, volume detection, sample

quality assessment, connection to analyzers via cobas

connection modules

¾¾ Four insort drawers provide capacity for up to 600

samples, eight outsort drawers can be configured for

up to 1,100 tubes and 41 sorting targets.



COBAS P 612 PRE-ANALYTICAL SYSTEM

A Complete Solution for Your Pre-analytics

Cobas p 612 pre-analytical system includes an aliquoting

section with barcode labeling of the secondary tubes and a

throughput of approx. 330 primary tubes/hour (depending

on number and volume of aliquots).

cobas p 512 and 612 pre-analytical systems could be

used as stand-alone systems or as a core part of a capable

pre-analytic solution. Therefore the following optional

features are available:



Connection to Centrifuges

The cobas p 471 and cobas p 671 centrifuge units offer

a comprehensive and flexible front-end automation

solution.

¾¾ Spinning with high g-forces



¾¾ Auto-balance function

¾¾ Flexible parameters

¾¾ Start timer.



Connection to Bulk Loader Module (BLM)

Convenient sample loading with a capacity of 600

samples reduces manual sample handling and guarantees

continuous sample flow. BLM can be connected in front

of the single centrifuge cobas p 471 (throughput up to

830 tubes per hour without centrifugation) or in front of

the pre-analytical system (throughput up to 1,100 tubes/

hour).



912



Concise Book of Medical Laboratory Technology: Methods and Interpretations



Camera Options

Smart features to detect the test volume

by infrared (IR-LLD) and to get information about sample

quality to identify hemolytic, icteric or lipemic samples are

available on cobas p 512 and p 612. This ensures automatic

quality assessment as well as early identification of

insufficient material.

Liquid level detection supports the aliquoting process –

no conductive tips are needed.



COBAS P 501 AND COBAS P 701

POST-ANALYTICAL UNITS

The automated archive

PRODUCT CHARACTERISTICS

¾¾ Storage throughput: up to 400 tubes/hour (storage)

¾¾ Retrieval throughput: up to 40 tubes/hour (retrieval,

without influence on storage throughput)

¾¾ Storage capacity:



13,000 tubes





27,000 tubes



¾¾ Retrieval of samples within 2 minutes after ordering



¾¾ Identification of primary sample tubes

¾¾ Automated storage, disposal and retrieval of sample

tubes

¾¾ Selective recapping of tubes for storage

ắắ Selective decapping of tubes for retrieval.



MODULARđ PRE-ANALYTICS EVO

Connecting Solutions of Excellence

MODULAR PRE-ANALYTICS EVO is a modular system for

the fully automated processing of primary samples from

centrifugation to archiving, including automated delivery

of samples to cobas 6000 analyzer series and cobas 8000

modular analyzer series. There are 3 models, plus options

and upgrades to provide the greatest flexibility. Thus, MPA

EVO meets a wide range of demands with regard to sample

throughput, laboratory layout, instruments connected and

functionalities.



YOUR BENEFIT

Full Automation

¾¾ Sample entry, result reporting and archiving

¾¾ Reduced biohazard risks for personnel.



Consolidation of Analytics

¾¾ Reduced complexity with fewer analyzers and fewer

process steps.



Process Organization

¾¾ Streamlining of processes by providing IT networking

of all components along with complete data and

workflow management.



Integration by Automation

¾¾ Shorter, predictable TAT

¾¾ Reduction of labor-intensive processes.



World’s Latest and Best Technologies by Roche



913



:Solution with all pre- and post-analytical steps including barcoded

aliquots for offline analyzer



PRODUCT CHARACTERISTICS

MPA EVO model A



MPA EVO model B



MPA EVO model C



Centrifugation















Decapping















Online aliquoting















Offline aliquoting















Barcode labelling















Recapping















Sorting/archiving















Primary tube workflow only















Online connection to:

MODULARđ ANALYTICS EVO

cobas 8000 modular analyzer series

• cobas 6000 analyzer series

• cobas p 501/701 post-analytical units















MPA options and upgrades:

• Primary sample sorter (PSS)

• Additional flexible sample sorter (FSS)

• 2nd centrifuge















3 different MPA models; A,B,C plus options and upgrades for the greatest flexibility.



COBAS® CONNECTION MODULES (CCM)

The New Perspective on Sample Flow Solutions

Cobas connection modules (CCM) enable the on-line

connection of cobas pre-analytical systems such as cobas

p 512 and cobas p 612 to different analyzers, MODULAR®

PRE-ANALYTICS EVO and post-analytical units.



CCM include pre-analytical systems as cobas p 512 or

cobas p 612 with a modified outsort and various conveyors

and turn-units to provide flexibility in design and on-site

upgradability of the conveyor layout.

Available in different versions*, CCM offer streamlined

solutions for high-throughput laboratories as well as

upgrade options for systems that are already connected.



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